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KMID : 0357920060400050361
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Korean Journal of Pathology
2006 Volume.40 No. 5 p.361 ~ p.367
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Immunohistochemical Characteristics of Kaposi Sarcoma and its Mimicries
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Lee Kyoung-Bun
Lee Hye-Seung
Lee Hee-Eun
Park So-Yeon
Chung Jin-Haeng
Choe Ghee-Young
Kim Woo-Ho
Song Kye-Yong
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Abstract
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Background: The differential diagnosis of Kaposi sarcoma includes many disease that range from benign disease to malignant tumors. However, little information is available about the immunohistochemical characteristics of Kaposi sarcoma.
Methods: The expressions of 13 various proteins (HHV-8 LNA-1, Ki-67, bcl-2, p53, CD31, CD34, factor VIII, D2-40, vimentin, SMA, S-100, EMA, and c-kit) were evaluated immunohistochemically in 49 vascular tumors including 16 Kaposi sarcomas, 8 angiosarcomas, 2 hemangioendotheliomas, and 23 benign vascular tumors with using the tissue array method.
Results: All 16 cases of Kaposi sarcoma showed nuclear staining for HHV-8 LNA-1, whereas all the cases of angiosarcoma and benign vascular lesions were negative for HHV-8 LNA-1 (p<0.001). All Kaposi sarcoma were positive for D2-40, which is a marker of lymphatic differentiation, but 25% of the benign vascular lesions and 30.4% of the angiosarcoma were positive for D2-40 (p<0.001). The mean proliferation index as assessed by Ki-67 immunostaining revealed no difference between the benign and malignant vascular lesions (p>0.05). No Kaposi sarcoma showed a bcl-2 expression, but 62.5% of the angiosarcomas and 21.7% of the benign vascular tumors had bcl-2 expressions (p= 0.005).
Conclusions: Immunohistochemical detection of HHV-8 LNA-1 and D2-40 are useful tools to differentiate Kaposi sarcoma from other vascular tumors.
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KEYWORD
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Sarcoma, Kaposi, Herpesvirus 8, human, Latent nuclear antigen, Monoclonal antibody D2-40, Immunohistochemistry
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